antifungal agents

Antifungals: Triazole, Polyene and echinocandin
1. Triazole
-inhibits ergosterol synthesis in the fungal cell wall by inhibiting lanosterol demethylase
-examples: fluconazole, itraconazole, voraconazole
-all azoles can cause hepatotoxicity, anaemia, thrombocytopenia, leukopenia, stevens-johnson syndrome, multiple drug interactions - increase levels of phenytoin, warfarin, cyclosporin

2. Polyene
-combines with sterols in fungal membrane to create a channel with leakage of cytosol
-e.g. Amphotericin, nystatin

3. Echinocandin
-inhibit synthesis of D-glucan, a key fungal cell wall component
-e.g. caspofungin, micafungin

what is right is always seen as wrong

Hi again,
thank you guys for visiting my site, it is not great but at least there are some important facts are discussed here.
The world that we live in is a mystery. It is very disheartening when people maybe talk and support about certain values, but on the other hand are fighting against the same facts and ideas.
I am trying to educate people at my work place based on my knowledge, expertise and experience, but people are uncomfortable and prefer to live in ignorance. Recently, I was asked to lower my expectation and quality of practice to their extremely dangerous level instead of striving to improve themselves. The irony is they wanted to be treated like adults but on the other hand required to be told all the instructions step-by-step.
My reminder to them is, alright...you can live in that situation but I won't because I want to live with the Physician's Oath that I had taken upon graduation 21 years ago. I keep wondering why they make it customary for us to read that oath out aloud if it is something that is not going to be lived by.